特任助教の豊田および卒業生のDoreen Kamoriの研究成果がScientific Reportsに発表されました。日本人HIV-1感染者のNef配列から、抗ウイルス因子であるSERINC5の阻害活性が弱くなる変異を同定しました。
A study led by an Assistant Professor Dr. Mako Toyoda and a former student Doreen Kamori has been published in Scientific Reports. She discovered a naturally occurring HLA-associated Nef mutations can impair Nef’s ability to counteract SERINC3/5 and are associated with lower plasma viral load in HIV-infected hosts.
Mako Toyoda, Doreen Kamori, Toong Seng Tan, Kageaki Goebuchi, Jun Ohashi, Jonathan Carlson, Ai Kawana-Tachikawa, Hiroyuki Gatanaga, Shinichi Oka, Massimo Pizzato, Takamasa Ueno
Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals.
Scientific Reports, accepted (2020)
DOI: 10.1038/s41598-020-76375-w
