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Ueno Lab.

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Division of Infection and Immunity,

Joint Research Center for Human Retrovirus Infection,

Kumamoto University

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​上野研究室
ヒトレトロウイルス学共同研究センター
感染予防部門 感染免疫学分野

Paper Published

更新日:2021年2月16日

特任助教の豊田および卒業生のDoreen Kamoriの研究成果がScientific Reportsに発表されました。日本人HIV-1感染者のNef配列から、抗ウイルス因子であるSERINC5の阻害活性が弱くなる変異を同定しました。


A study led by an Assistant Professor Dr. Mako Toyoda and a former student Doreen Kamori has been published in Scientific Reports. She discovered a naturally occurring HLA-associated Nef mutations can impair Nef’s ability to counteract SERINC3/5 and are associated with lower plasma viral load in HIV-infected hosts.

Mako Toyoda, Doreen Kamori, Toong Seng Tan, Kageaki Goebuchi, Jun Ohashi, Jonathan Carlson, Ai Kawana-Tachikawa, Hiroyuki Gatanaga, Shinichi Oka, Massimo Pizzato, Takamasa Ueno

Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals.

Scientific Reports, accepted (2020)

DOI: 10.1038/s41598-020-76375-w




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Ueno Lab.

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Ueno Laboratory

Division of Infection and Immunity,

Joint Research CenterforHuman Retrovirus Infection, Kumamoto University

2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811 Japan

Tel  096-373-6824

上野研究室

860-0811  熊本市中央区本荘2-2-1  

熊本大学ヒトレトロウイルス学共同研究センター感染免疫学分野

電話番号  096-373-6824

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